Determination of drug-polymer solubility from supersaturated spray-dried amorphous solid dispersions: A case study with Efavirenz and Soluplus®
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چکیده
منابع مشابه
Drug-polymer miscibility across a spray dryer: a case study of naproxen and miconazole solid dispersions.
The structural and physical stability of solid dispersions have not been adequately explored during spray drying manufacturing processes. In this study a wide range of compositions of naproxen/PVP-VA 64 (poly(1-vinylpyrrolidone-co-vinyl acetate)) and miconazole/PVP-VA 64 solid dispersions prepared by different laboratory spray dryers were collected from various selected locations and used to in...
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In the injection moulding process the manufactured plastic components may carry asignificant amount of charge which has undesirable consequences in some applications e.g.in dry powder inhalers (DPI's). In high resistivity polymers, the charge may lie in the bulk ofthe material which prevents typical neutralizing procedures such as use of ionizers. Insteadof neutralizing the ...
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The bioavailability of hydrophobic drugs strongly increases if they are formulated as amorphous materials because the solubility of the amorphous phase is much higher than that of the crystal. Moreover, the stability of these particles against crystallization during storage increases with decreasing particle size. Hence, it is advantageous to formulate poorly water soluble drugs as amorphous na...
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This work explores the use of both spray drying and d-glucosamine HCl (GLU) as a hydrophilic carrier to improve the dissolution rate of piroxicam (PXM) whilst investigating the electrostatic charges associated with the spray drying process. Spray dried PXM:GLU solid dispersions were prepared and characterised (XRPD, DSC, SEM). Dissolution and triboelectric charging were also conducted. The resu...
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ژورنال
عنوان ژورنال: European Journal of Pharmaceutics and Biopharmaceutics
سال: 2019
ISSN: 0939-6411
DOI: 10.1016/j.ejpb.2019.06.028